NFL Week 1 Odds 2026: Spreads, Totals and Moneylines for Every Game

Favorites went 9-7 against the spread in Week 1, and the totals split eight overs and eight unders. Underdogs won four games outright, with the Cardinals beating the Chargers 26-14 as 10.5-point underdogs. Bears at Panthers combined for 96 points against a total of 47.5.
Lines are DraftKings’ spread, total and moneyline as listed on Covers on Sept. 4, before the week’s games kicked off, so they aren’t closing lines. The ESPN columns show the DraftKings spread and total on each game’s ESPN page, and the ATS and O/U results are graded against the Covers line. Two results change on ESPN’s numbers: Patriots at Seahawks is a push at SEA -3, and Cowboys at Giants goes over a total of 47.5.
Novig lists the same games as contracts and charges no fee on pre-game straight trades, so the contract price is the whole cost of a pre-game trade, with no -110 margin on top.
Matchup | Spread (Covers) | Spread (ESPN) | Total (Covers) | Total (ESPN) | Moneyline (Covers) | Final | ATS | O/U |
|---|---|---|---|---|---|---|---|---|
NE at SEA | SEA -3.5 | SEA -3 | 44.5 | 44.5 | NE +154 / SEA -185 | NE 10, SEA 13 | NE covered | Under |
SF at LAR | LAR -3.5 | LAR -3.5 | 48.5 | 47.5 | SF +164 / LAR -198 | SF 27, LAR 7 | SF covered | Under |
TB at CIN | CIN -3.5 | CIN -3.5 | 51.5 | 50.5 | TB +170 / CIN -205 | TB 27, CIN 33 | CIN covered | Over |
NO at DET | DET -7.5 | DET -7 | 49.5 | 49.5 | NO +250 / DET -310 | NO 30, DET 31 | NO covered | Over |
NYJ at TEN | TEN -1.5 | TEN -1.5 | 38.5 | 39.5 | NYJ +110 / TEN -130 | NYJ 23, TEN 10 | NYJ covered | Under |
BAL at IND | BAL -3.5 | BAL -3 | 48.5 | 48.5 | BAL -175 / IND +145 | BAL 41, IND 23 | BAL covered | Over |
ATL at PIT | PIT -3.5 | PIT -6.5 | 42.5 | 40.5 | ATL +154 / PIT -185 | ATL 13, PIT 20 | PIT covered | Under |
CHI at CAR | CHI -2.5 | CHI -3 | 47.5 | 47.5 | CHI -148 / CAR +124 | CHI 59, CAR 37 | CHI covered | Over |
CLE at JAX | JAX -7.5 | JAX -8.5 | 40.5 | 40.5 | CLE +310 / JAX -395 | CLE 10, JAX 34 | JAX covered | Over |
BUF at HOU | BUF -1.5 | BUF -1.5 | 44.5 | 44.5 | BUF -118 / HOU -102 | BUF 36, HOU 31 | BUF covered | Over |
MIA at LV | LV -3.5 | LV -3 | 40.5 | 40.5 | MIA +164 / LV -198 | MIA 13, LV 27 | LV covered | Under |
GB at MIN | MIN -1.5 | MIN -2.5 | 45.5 | 46.5 | GB -102 / MIN -118 | GB 22, MIN 39 | MIN covered | Over |
WAS at PHI | PHI -5.5 | PHI -6 | 44.5 | 43.5 | WAS +180 / PHI -218 | WAS 22, PHI 24 | WAS covered | Over |
ARI at LAC | LAC -10.5 | LAC -8.5 | 46.5 | 47.5 | ARI +455 / LAC -625 | ARI 26, LAC 14 | ARI covered | Under |
DAL at NYG | DAL -2.5 | DAL -3 | 48.5 | 47.5 | DAL -148 / NYG +124 | DAL 20, NYG 28 | NYG covered | Under |
DEN at KC | KC -2.5 | KC -2.5 | 42.5 | 42.5 | DEN +124 / KC -148 | DEN 10, KC 31 | KC covered | Under |